This panel discussion examines the application of Human Performance principles to improve safety and operational reliability in deepwater and topsides environments. The session focuses on how leading operators, and service companies use system-based approaches to understand performance variability, manage active and latent error, and strengthen decision-making under complex operating conditions. Drawing on field experience, the discussion will highlight the shift from a blame-oriented model to a learning-focused just culture that improves identification of organizational and supervisory influences on frontline work while maintaining clear accountability. Attendees will gain insight into practical implementation through job planning, communication, supervisor engagement, and leadership behaviors that shape safe execution at the point of work and support sustained performance improvement.